Logo of PURE5 Extraction systems company
Close this search box.

The Endocannabinoid System and our Body

Healthy human being energized adn purified


Dr. George Stantchev
Dr. George Stantchev

PHD, MBA, MSEE, Entrepreneur and CEO of most innovative extraction technology company.

What does Hemp give us?

In recent years, there has been a lot of talk about cannabidiol (also called CBD oil), its effects and its potential as a therapeutic agent in the fight against depression, anxiety, burn-out syndrome, excessive stress, insomnia, and even cancer.

CBD is one of the main cannabinoids in the industrial hemp (plant Cannabis Sativa). However, very few of us know exactly what causes its action, we do not know what it does and how it works.

Before we start talking about the CBD molecule, however, we need to understand what the endocannabinoid system (ECS) is, the one that is responsible for the observed effects of cannabidiol, as well as a basic mechanism that is embedded in the way our bodies function.a graphic of the health benefits of endocannabinoid system with a body and its benefits around it explained

What is the endocannabinoid system?

At school we have learned that there are 10 basic body functional systems in the human body. Those are the circulatory system, the respiratory system, the excretory system, the reproductive system, the nervous system, the muscular system, the endocrine system, the lymphatic system and the gastrointestinal system.

Did you know that in addition to the above-mentioned systems, there is also an endocannabinoid system (ECS)? Of course not, because if you are not a doctor or do not work with medical cannabis, it is unlikely that you will read about it. And still some scientists call the ECS system “the most important physiological system that participates in the establishing and maintaining of human health.”

Imagine that cell receptors in the body are a series of houses, each of them has a set of keys. These receptor keys are chemical molecules called “agonists.” Each time an agonist attaches to a cell receptor, it sends a signal and gives a specific order to the cell. 

The endocannabinoid system consists of two primary cellular receptors – CB1 and CB2. The agonists or keys to these receptors are actually cannabinoids that are produced in the body, but also cannabinoids that enter the body from the external environment, such as those from CBD oil.

What is the endocannabinoid system (ECS)?

We do not have a full cap on what the ECS does, but we know that the ECS helps to fine-tune most of the vital physics. It promotes homeostasis and affects the processes that regulate sleep, appetite, pain, inflammation, memory, nausea and even depression. The ECS helps to regulate homeostasis in all major systems of the body, which guarantees that all systems work together.

It is often mistakenly thought that endocannabinoid receptors are found exclusively in the brain. This is not entirely true, as they can be found in some glands as well as in immune cells. The functions of the receptors are mainly to maintain the balance in the body and to monitor the proper course of homeostasis.

The receptors that act as locks in the endocannabinoid system are CB1 and CB2.

  • CB1 receptors are found in abundance mainly in the central nervous system (CNS) – the cerebral cortex, basal ganglia, hypothalamus, cerebellum and less in the periphery.
  • CB2-receptors predominate in the tissues of the immune system – spleen, tonsils, thymus, immune cells.

Every lock needs a key.

The keys that unlock the receptors are called ligands. These are small biologically active molecules that interact with receptors in different ways and “unlock” them.

They can also be produced by the human body, and in ECS such ligands are anandamide (its name comes from the Sanskrit word “ananda”, which means bliss) and 2-arachidonoyl glycerol.

When ligands are imported into the body from the outside, they have an exogenous origin. In our case, these are the molecules of CBD and THC (Tetrahydrocannabinol).

By their action, exogenous ligands can be agonists (resembling the effect of an endogenous ligand) or antagonists (bind to the receptor and block the action of endogenous ligands).

Although studies of the endocannabinoid system are still very fragile, they are very promising in terms of the use of cannabinoids in the treatment of a number of diseases.

Scientists have found that ECS plays an immediate role in homeostasis by regulating the proper course of all metabolic processes in the body.

The endocannabinoid system plays a role in processes such as:

  • mood regulation
  • appetite
  • memory
  • inflammation
  • pain sensation
  • muscle tone and movement
  • erasing traumatic memories
  • protecting nerves and brain tissue
  • bone growth
  • regulation of tumors
  • pleasure in breastfeeding
  • stress management
  • intraocular pressure
  • gastrointestinal peristalsis
  • seizures
  • and many others

In this regard, the extracts used in Pure For Life products are obtained with extraction at room temperature preserving the vital properties of the plant and increasing the potency of the product in which this extract is used. PURE5™’s patented technology is a key component for the production of high quality products with high medical performance. 

Who we are?

At PURE5™ Extraction, we design and manufacture cost- and process-optimized cannabis extraction equipment and systems, as well as applicable post-processing stages targeting specific end products. COMERG is committed to offering the fastest, safest, and most economical extraction process for Cannabis sativa oils named Pure Botanical Extraction (PBXTM) standard.

Our technology originated from building machines for fragrance and flavor production in Europe utilizing various solvents as hexane, steam, ethanol and R134a. This technology alone and with the combination of ethanol has been used for extracting various herbs. The consistency and the economics have been proven over a couple of decades. Based on that vast experience, COMERG developed equipment differentiated by processing capacity. 


For inquiries contact:

Dr. George Stantchev, CEO

(602) 992-0744

Related posts:

Cannabis rosin extract slipping down in liquid form and some hemp leaves around it showcasing the big yield output of the r-134a equipment

High Yield Cannabis Extraction

High Yield Cannabis Extraction: Maximizing Output with R-134a Aerosol solvent In the rapidly evolving cannabis industry, efficient and high yield